Pioneer of bioinfomatics services 　Since we had participated in the Japan-U.S. collaborative project in bioinformatics through the Institute for New Generation Computer Technology (ICOT) in 1990, our company has contributed to produce numerous public databases and analytical services using the latest IT technology. This has been developing products from scratch to meet the diverse and advanced requirements of our customers in this rapidly evolving field of life sciences. 　Outline of major achievements 　We have succeeded in developing databases with various fundamental functions of bioinformatics, such as homology search, multiple alignment, gene discovery, ontology and so on. Further, we have produced numerous stable web services with SOAP using parallel computers and grid computation for high-load sequence analysis, protein identification search, protein structural analysis and so on. We have been able to reduce costs, since maintenance is seldom necessary during stable operation of these systems. 　Our company has ISO 14001 certification as a company that promotes environment management policies for contributing to the elimination of global environmental problems. 　Click here for a list of elemental technology we have been involved with to date. 　Contributions to academia 　We benefit from a cooperative relationship with a number of academic institutions, and in return we grant academic institutions free access to R Graphical Manuals , which is already frequently accessed by major research organizations and companies all around the world, as well as eGHack Database , a catalogue database of microbial genes predicted by GeneHacker Plus. We also developed Tissue DB ,provides a comprehensive hierarchical nomenclature for human histological structures. 　Large-scale projects 　We respond quickly with low-cost solutions for large-scale projects in the life-sciences field. Our company was involved in the ground system development for the phased array type L-band synthetic aperture radar (PALSAR), one of the most important features of the satellite “Daichi” launched by the Japan Aerospace Exploration Agency (JAXA). We exercised leadership in the project, participating from the initial proposal stage. We have also collaborated with U.S. companies in high-tech areas including synthetic aperture radar. Further, we were responsible for developing the system integrator (over 100 personnel involved) for the Japanese side of the ASTER project in cooperation with NASA in the U.S., which was the pioneering project in this area. This ground system, which is in the over 100-terabyte class, has continued extremely stable 24-hour operation for nearly 10 years. 　Measures to combat security problems 　We provide security engineering services, making use of our comprehensive security know-how. Specifically, we offer design, installation, testing and operation and support services with respect to system security. Our achievements include the creation of a secure, 24-hour electronic commerce site which can be franchised. We are also involved in promoting the Certified Information Systems Security Professional (CISSP) qualification, which is considered the premiere certification worldwide. We also run system security engineering process ability testing using means such as ISO/IEC 21827 (SSE-CMM). 　Basic technology R graphical manuals Grid computing using Globus Toolkit and Condor Web services for various types of bio-applications using SOAP System design for large-scale proteome experiment laboratory Parallel computation on various parallel computers, PC clusters Parallelization of programs using MPI, openmp, pthread, SSE, SSE2, SSE3 3-dimensional display of proteins Integrated system of genome analysis with XML Automatic measurement of nerve axis length using image processing of microscope photographs Data analysis of microarray expression using drug discoveries and medical statistics and tests Data creation for patent applications based on the patent application format for large amount of gene protein data 　Analysis of DNA and amino acid sequence eGHack DB , a catalogue database of microbial genes predicted by GeneHacker Plus Database and analysis system of functional RNA (ncRNA etc.) Gene discovery in silico(prokaryotes, eukaryotes, GPCR, glycosyltransferase, etc.) Basic research about multiple alignment and its parallel computation Motif extraction and Motif searching, palindrome analysis Prediction of gene expression conditions Attribution of 3D structure of ORF Database of alternative splicing 　Annotation, ontology, natural language processing Database of localization informations of mRNAs and proteins of signaling molecules ( Tissue DB, its paper) Extraction of PubMed terminology and KWIC (Key Word in Context) analysis Gene annotation (eukaryotes, prokaryotes, GPCR, etc.) Database of Cancer gene expression linked to disease cases (disease factors) Ontology pathway database 　Analysis of protein Docking calculation Prediction of GPCR binding G proteins with SVM Protein identification using MS/MS mass spectrometry Database of Enzyme-catalyst mechanism Database of classification of sugar chains by structure Protein profiling with HMM Protein structure similarity search Simulation of association of synthetic peptides Parallel molecular dynamics program considering long-distance Coulomb force (Ewald method, PME method, PPPC method, FMM method) Prediction of 3D/2D structure of protein